Antioxidant defense and aging in C. elegans: is the oxidative damage theory of aging wrong?
نویسندگان
چکیده
The oxidative damage theory of aging once seemed almost proven. Yet recently the buzzards have been assembling in the blue skies above it. New challenges to the theory from work using nematode worms seem set to bring them down to peck at its bones. But is the theory really dead, or does it just need to be modified?
منابع مشابه
of the Faculty of Medicine in Niš 2014
Skin aging is a dynamic process that occurs due to chronological and photo-aging caused by the influence of external factors, especially ultraviolet-UV radiation. Cumulative oxidative stress, formation of free radicals and their adverse effects on biological systems in the skin cells is a common mechanism of both skin aging processes. The formed reactive oxygen species-ROS can lead to the oxida...
متن کاملEvaluation of antioxidant activity of natural product compounds from Platycladus orientalis leaves
Background and objectives: Natural product compounds of plants have been used since ancient times and in folklore medicine for the treatment of many diseases and illnesses. Oxygen-centered free radicals and other reactive oxygen species, which are continuously, produced in vivo, result in cell death and tissue damage. Oxidative damage caused by free radicals may be rel...
متن کاملتئوریهای بیوشیمیایی و ژنتیکی فرایند پیری
Aging is the outcome of the progressive accumulation of different alterations in the body which accompanied with gradual decrease of the efficiencies of normal physiological functions and the capacity to maintain homeostasis that lead to the increase in disease probability and the death of people. The researchers have done different experiments especially on animal models for the perception of ...
متن کاملAlternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction?
SIGNIFICANCE The biological mechanisms at the heart of the aging process are a long-standing mystery. An influential theory has it that aging is the result of an accumulation of molecular damage, caused in particular by reactive oxygen species produced by mitochondria. This theory also predicts that processes that protect against oxidative damage (involving detoxification, repair, and turnover)...
متن کاملEffects and mechanisms of prolongevity induced by Lactobacillus gasseri SBT2055 in Caenorhabditis elegans
Lactic-acid bacteria are widely recognized beneficial host associated groups of the microbiota of humans and animals. Some lactic-acid bacteria have the ability to extend the lifespan of the model animals. The mechanisms behind the probiotic effects of bacteria are not entirely understood. Recently, we reported the benefit effects of Lactobacillus gasseriSBT2055 (LG2055) on animal and human hea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cell cycle
دوره 8 11 شماره
صفحات -
تاریخ انتشار 2009